A drug reaction can resemble a wide range of skin lesions. Drugs such as traditional drugs, biological agents and food additives, and colors can be among the causative factors in addition to the usual drugs. Medications can also cause itching without obvious skin lesions. In any patient who takes medicine and suddenly develops symmetrical skin lesions, the reaction caused by the medicine should be considered.

The first step is to review the patient’s complete medication list, including over-the-counter supplements. Any history of previous reactions to drugs or foods should be investigated. Note any concomitant infections, metabolic disorders, or immunodeficiency (eg, due to HIV infection, cancer, chemotherapy) as these increase the risk of drug reaction.

The risk of drug reactions in immunocompromised people is 10 times higher than in the general population. The frequency of drug sensitivity reactions, including severe reactions (eg, TEN), is significantly increased in HIV-positive individuals.

Considering that some drug reactions are severe and can be dangerous for the patient, drug reactions should be taken seriously and more investigations should be done in case of involvement of the mouth, lips and genital area.

Treatment :

The ultimate goal is always to stop the offending drug if possible. People with drug reactions often take the most medications, many of which are necessary for their survival. However, all unnecessary medications should be limited. Once the offending drug is identified, its use should be stopped immediately. Treatment is determined based on the type and severity of the drug reaction.